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. 2021 Oct 12;13(10):1668. doi: 10.3390/pharmaceutics13101668

Figure 8.

Figure 8

NK cell−mediated killing of U87 cells and degranulation activity. U87 cells were treated with MHT and co−cultured with IL−2−activated NK cells for 4 h at an E:T ratio of 1:1. Tumor cell killing of U87 cells was assessed via flow cytometry determining viability dye-positive (FSV450+) cells in U87 cells. (a) Data are shown as representative histograms (a) and mean ± SEM (b). IL−2−activated NK cells were co−incubated with U87 cells for 4 h at an E:T ratio of 1:1 in the presence of anti−CD107a antibody. The percentage of degranulating CD107a+/CD56+ NK cells was represented as individual plots (c) and mean ± SEM (d). Results shown are representative of three experiments using NK cells from two healthy donors. Statistical analysis was performed using a one−way ANOVA test (** 0.001 < p < 0.01; *** p < 0.001; n.s. = not significant).