Table 2.
Melting temperatures (Tm) of tel26 and c-myc G4s or ds27 duplex in the absence or presence of the ligands (10 molar equivalents) as measured by CD-melting experiments.
| tel26 * | c-myc ** | ds27 * | ||||
|---|---|---|---|---|---|---|
| Tm (°C) (±1) | ΔTm (°C) | Tm (°C) (±1) | ΔTm (°C) | Tm (°C) (±1) | ΔTm (°C) | |
| No ligand | 40 | 45 | 75 | |||
| Bulbocapnine | 41 | +1 | 54 | +9 | 74 | −1 |
| Chelidonine | 44 | +4 | 58 | +13 | 74 | −1 |
| Ibogaine | 42 | +2 | 50 | +5 | 75 | 0 |
| Rotenone | 40 | 0 | 49 | +4 | 75 | 0 |
| Vomicine | 40 | 0 | 50 | +5 | 72 | −3 |
* In 5 mM KCl, 5 mM phosphate buffer, 5% DMSO (pH 7), ** In 0.5 mM KCl, 0.5 mM phosphate buffer, 5% DMSO (pH 7).