Figure 2.

Body temperature and clinical signs in sheep. Prime-boost DISA12348 vaccinated groups and two challenge control groups were challenged on day 84 of the experiment (0 dpc) (arrow) with virulent BTV2 (blue, squares) or virulent BTV8 (red, circles). The average daily body temperature per group was calculated for vaccinated groups (open symbols) and control groups (filled symbols). Clinical signs were quantitatively monitored and the total clinical score for each group per day was calculated for vaccinated groups (striped bars) and control groups (filled bars). Neither elevated body temperature nor clinical signs were observed after the DISA12348 vaccination (not shown).