Table 3.
Case details of cases of suspected FCV-VSD in Outbreak 3 in the Australian Capital Territory (ACT) in 2018 and the suspected case of origin, disease phenotype, time until first appearance of cytopathic effects (CPEs) in viral culture, duration of illness and outcome.
| Case | Date in 2018 | Breed, Sex | Age | Origin | Vacc. Status |
Exposure History and Clinical Signs (CS) |
Disease Phenotype | CPEs | Duration of Illness | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| ACT_1 **,1,2 Index case |
22/01 | DSH FN |
4 m | MCH | Incomp. | Fever, inappetence, lameness, polyarthropathy. Adopted from a shelter. |
URTD | 36 h | 14 d | R |
| ACT_2 **,1,2 Index case |
22/01 | DSH MN |
4 m | MCH | Incomp. | Fever, lethargy, sneezing. Adopted from a shelter. |
URTD | 36 h | 14 d | R |
| ACT_3 ****,1,2 | 23/01 | DSH M |
10 y | MCH | Unvacc. | No CS. Adopted from a rescue society. Presented on 23/01 for a dental procedure. |
Asympt. | 60 h | N/A | N/A |
| ACT_4 **** | 30/01 | DSH FN |
5 y | MCH | Complete | Fever, pain on abdominal palpation, limb oedema, myopathy, creatine kinase 20,206 U/L (RR < 261); AST 487 U/L, (RR < 60), myoglobinuria. Indoor cat co-housed with ACT_3. Onset of CS 7 days after ACT_3 had a dental procedure. |
VSD | N/A | 9 d | R |
| ACT_5 | 02/02 | DSH MN |
8 y | MCH | Complete | Fever, inappetence, hypersalivation, jaundice, lumbar muscle pain, facial/limb oedema, ulcerated nasal planum. Onset of CS 4 days after a dental procedure. |
VSD | N/A | 21 d | R |
| ACT_6 *** | 07/02 | DSH FN |
5 y | MCH | Complete | Vomiting, fever, painful kidneys on abdominal palpation, marked facial and limb oedema (all limbs), subcutaneous oedema of flanks, oral ulcers, swollen nose. Onset of CS 14 days after dental check-up. |
VSD | N/A | 10 d | R |
| ACT_7 *,1,2 | 08/02 | Maine Coon MN |
10 m | MCH | Complete | Fever, inappetence, oral ulcers. Onset of CS 8 days after ACT_8 had a dental procedure. |
URTD | 48 h | 7 d | R |
| ACT_8 * | 08/02 | DSH MN |
15 y | MCH | Unknown | Fever, inappetence, nasal planum ulcers. Onset of CS 8 days after being admitted to the hospital for a dental procedure. |
URTD | 12 d | R | |
| ACT_9 ***,1,2 | 14/02 | Ragdoll cross MN |
4 y | MCH | Comp. | Fever, inappetence, lethargy, facial/limb oedema, swollen nose. Indoor cat co-housed with ACT-6. | VSD | 36 h | 7 d | R |
* From same household; ** from same household; *** from same household. **** from same household 1 Samples collected for viral culture. 2 Whole-genome sequencing performed. Comp., complete; CS, clinical signs; D, died; DSH, domestic shorthair; E, euthanised; F, female; FN, female neutered; Incomp., incomplete; M, male; MN, male neutered; MCH, multicat household; N/A, not applicable; R, recovered; SCH, single-cat household; Unvacc., unvaccinated; URTD, upper respiratory tract disease; Vacc., vaccinated; VSD, virulent systemic disease; wks, weeks; y, years.