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. 2021 Oct 7;10(10):1291. doi: 10.3390/pathogens10101291

Figure 6.

Figure 6

Cytokine productions in the lung homogenates (n = 3) were quantified. (A,B) IFN-γ and IL-6 productions in the lung samples were assessed following 10 LD50 challenge infection. (C,D) IFN-γ and IL-6 productions in the lung samples were quantified using cytokine ELISA after 2 LD50 challenge infection. Data are presented as median ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001) and are representative of the two independent immunization studies conducted on mice. Abbreviations: Naïve + cha—unimmunized infection control; HA VLPs—virus-like particles (VLPs) expressing hemagglutinin (HA) antigen only; NA VLPs—VLPs expressing neuraminidase (NA) antigen only; HANA VLPs—VLPs expressing both HA and NA antigens; M1 VLPs—VLPs expressing only M1 antigen.