Figure 8.

Bodyweight reductions and survival of mice (n = 6) were monitored for 11 days post-challenge infection with high and low doses of avian influenza virus. (A,B) After challenge infection with 10 LD₅₀, bodyweight and survival were measured. (C,D) Bodyweight reduction and survival data of low dose challenge infection (2 LD₅₀). Data are presented as mean ± SD (* p < 0.05) and are representative of the two independent immunization studies conducted on mice. Abbreviations: Naïve + cha—unimmunized infection control; HA VLPs—virus-like particles (VLPs) expressing hemagglutinin (HA) antigen only; NA VLPs—VLPs expressing neuraminidase (NA) antigen only; HANA VLPs—VLPs expressing both HA and NA antigens; M1 VLPs—VLPs expressing only M1 antigen.