Table 1.

ΔG in kcal/mol for reactions in the oxidative TCA cycle with co-factors.

Step	Reaction	Textbook	Alberty	Quantum
1	acetyl-CoA + oxaloacetate + H2O → citrate + CoA	−7.5	−10.7	−4.5
2	citrate → cis-aconitate + H2O	+2.0	+2.0	+3.8
3	cis-aconitate + H2O → isocitrate	−0.5	−0.4	−3.0
4	isocitrate + NAD+ → α-ketoglutarate + CO2 + NADH	−2.0	−1.1	−0.3
5	α-ketoglutarate + NAD+ + H2O + Pi + ADP → succinate + CO2 + NADH + ATP	−8.0	−8.6	−10.5
6	succinate + FADenzox → fumarate + FADenzred	~0	0.0	N/A
7	fumarate → malate	−0.9	−0.9	−1.2
8	malate + NAD+ → oxaloacetate + NADH	+7.1	+6.9	+8.0
	Net Cycle:	−9.8	−12.7	−7.7