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. 2021 Sep 29;11(10):1025. doi: 10.3390/life11101025

Table 4.

ΔG in kcal/mol for the cycle designed by Muchowska et al.

Step Reaction eQuilibrator Quantum Jankowski
1 GLX + PYR → maloylformate −3.09 −2.63 −0.75
2 maloylformate → fumaroylformate + H2O not available +0.78 +3.73
3 fumaroylformate + H2 → AKG not available −26.88 −22.33
4 AKG + GLX → isocitroylformate not available +0.30 −2.56
5 isocitroylformate + 2 H2O → ISC + H2CO3 + H2 not available −9.28 −7.40
6 ISC → GLX + SUC +1.39 +1.00 +5.08
7 SUC → FUM + H2 +23.78 +27.12 +19.12
8 FUM + H2O → MAL −0.74 −1.22 −3.73
9 MAL → OXA + H2 +14.60 +15.08 +8.02
10 OXA + H2O → PYR + H2CO3 −5.16 −4.49 −14.64
Net Cycle: N/A −0.22 −15.46
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