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. 2021 Sep 23;14(10):960. doi: 10.3390/ph14100960

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effects of different dosages of CaSR agonist (AC) on micturition. (a) Illustration of micturition function parameters that were measured in this study. Effects of intravesical administrations of 10 µM AC (b) (n = 3), 100 µM AC (c) (n = 3), and 1 mM AC (d) (n = 6) on micturition with the recording of intravesical pressure (IVP) and blood pressure (BP). The statistical analysis of micturition function parameters before (saline) and after different treatments, including inter-contraction-intervals (ICI) (e), phase 1 IVP (f), amplitude of phase 2 oscillation (g), baseline pressure (h), voiding duration (i), amplitude of non-micturition contractions (NMCs) (j), and bladder compliance (k) (Two-way ANOVA with Sidak’s post hoc tests; * p < 0.05, ** p < 0.01, *** p < 0.001, as compared with saline treatment in each group).