Table 1.
Selected genes and single nucleotide polymorphisms evaluated in the OBEGEN study.
| Gene | Name | Chromosome Allocation of Human Ortholog | SNP |
|---|---|---|---|
| ACE | angiotensin I converting enzyme | 17q23.3 | rs4343 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | 3q27.3. | rs16861209 rs2241766 |
| ADRB3 | adrenoceptor beta 3 | 8p11.23. | rs4994 rs9693898 |
| AGRP | Agouti related neuropeptide | 16q22.1 | rs11575892 * |
| AGTR1 | angiotensin II receptor type 1 | 3q24. | rs5186 |
| APOA2 | apolipoprotein A2 | 11q23.3. | rs5082 |
| APOA5 | apolipoprotein A5 | 11q23.3. | rs651821 |
| APOC3 | apolipoprotein C3 | 11q23.3. | CD010 |
| BDNF | brain derived neurotrophic factor | 11p14.1. | rs6265 rs925946 |
| CCDC93 | coiled-coil domain containing 93 | 2q14.1 | rs10490628 * |
| CDKAL1 | CDK5 regulatory subunit associated protein 1 like 1 | 6p22.3. | rs7754840 |
| CDKN2B | cyclin dependent kinase inhibitor 2B | 9p21.3. | rs10811661 |
| CLOCK | clock circadian regulator | 4q12. | rs4580704 rs4864548 |
| CNR1 | cannabinoid receptor 1 | 6q15 | rs6454674 * |
| ELOVL6 | ELOVL fatty acid elongase 6 | 4q25. | rs682447 |
| ESR1 | estrogen receptor 1 | 6q25.1 | rs3778099 * |
| FTO | fat mass and obesity associated | 16q12.2. | rs9939609 |
| GHRL | ghrelin and obestatin prepropeptide | 3p25.3. | rs696217 |
| IGF2 | insulin like growth factor 2 | 11p15.5 | rs680 * |
| INSIG2 | insulin induced gene 2 | 2q14.1. | rs7566605 rs3771942 * |
| IL-1B | interleukin 1 beta | 2q14.1 | rs1143643 * |
| IL6 | interleukin 6 | 7p15.3. | rs1800795 |
| LEP | leptin | 7q32.1. | rs12535708 |
| LEPR | leptin receptor | 1p31.3. | rs1137100 |
| LPL | lipoprotein lipase | 8p.22. | rs328 |
| MC4R | melanocortin 4 receptor | 18q21.32. | rs12970134 rs52820871 rs17700633 rs2229616 rs17782313 |
| MTCH2 | mitochondrial carrier 2 | 11p11.2. | rs10838738 |
| NEGR1 | neuronal growth regulator 1 | 1p31.1 | rs2568958 * |
| PLIN1 | perilipin 1 | 15q26.1. | rs1052700 rs894160 |
| PPARA | peroxisome proliferator activated receptor alpha | 22q13.31. | rs1800206 |
| PPARG | peroxisome proliferator activated receptor gamma | 3p25.2. | rs1801282 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 5q15. | rs6235 |
| PON1 | paraoxonase 1 | 7q21.3. | CD014 |
| SIRT1 | sirtuin 1 | 10q21.3 | rs7069102 * |
| TCF7L2 | transcription factor 7 like 2 | 10q25.2. | rs7903146 |
| TMEM18 | transmembrane protein 18 | 2p25.3 | rs2867125 * |
| UCP1 | uncoupling protein 1 | 4q31.2 | rs45539933 * |
| UCP2 | uncoupling protein 2 | 11q13.4. | rs659366 |
| UCP3 | uncoupling protein 3 | 11q13.4. | rs1800849 |
| WFS1 | wolframin ER transmembrane glycoprotein | 4p16.1. | rs10010131 |
SNP: single nucleotide polymorphism. *: Genetic variants that have been added from the pilot study [17].