Figure 6.

Relative expression of genes related to (a) liver steatosis and (b) liver fibrosis. The effects of a 7- and 28-day exposure to CyA 5 µM and of a 28-day exposure to PQ 2 µM and TRI 100 µM were assessed by microarray analysis in at least 75 spheroids from each PHH donor. Absolute fold changes in gene expression above 1.5 were considered significant. All the gene names are listed in Table S2 in the supplementary materials. CyA—cyclosporine-A; d—day; PHH—primary human hepatocytes; PQ—paraquat; TRI—triclosan.