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Effect of pH on virus activity.
| pH | Sensitization Time (s) | Viral Titer (TCID50/mL) |
|---|---|---|
| 5 | 300 | 4.8 ± 0.2 1 |
| 7.5 | 300 | 4.9 ± 0.4 |
| 10 | 300 | 5.0 ± 0.2 |
| 11 | 300 | 4.4 ± 0.1 |
| 12 | 300 | 3.6 ± 1.4 |
| 12.4 | 300 | ≤0.5 ± 0 |
| 60 | ≤0.5 ± 0 | |
| 30 | ≤0.8 ± 0.6 | |
| 13 | 300 | ≤0.5 ± 0 |
| 60 | ≤0.5 ± 0 | |
| 30 | ≤0.5 ± 0 |
Aliquots of virus (SARS-CoV-2/WK-521, 107.0 ± 0.3 TCID50/mL) were mixed with nine volumes of pH-adjusted DMEM (from pH 5 to 13) and incubated at 20 °C. 1 Mean ± standard deviation of three independent experiments.
