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. 2021 Sep 28;11(10):658. doi: 10.3390/metabo11100658

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of viable metabolite presence and gross abundance across sample matrices. Venn diagrams in (C) show the number of metabolites viably detected above the noise level in mitochondria, cytosols and both compartments for the whole-brain and quadriceps matrices, separately. Heatmaps of average matrix raw peak abundances, contrasted by Euclidian between-mean distances, are presented for the (B) total viable LC-MS/MS and (A) ¹H-NMR features. Br.C and Br.M abbreviate averages for whole-brain cytosolic and mitochondrial fractions, respectively, and Qu.C and Qu.M indicate quadriceps muscle cytosolic and mitochondrial groups.