Table 3.
Tail-flick test in mice. Percent Maximum Possible Effect (MPE), Area under the curve (AUC) and time of anesthesia for the hydrogel lidocaine formulations (HGel-LDC), hydrogel plus NLCCTRL (HGel-NLCCTRL) and hydrogel plus NLC and docetaxel (HGel- NLCDTX-LDC).
| Formulation | MPE ± SD (%) | AUC ± SD | Time of Anesthesia (min) |
|---|---|---|---|
| HGel-LDC | 88.48 ± 11.39 | 3545.8 ± 821.1 | 150 |
| HGel-NLCCTRL-LDC | 88.85 ± 15.84 | 3882.8 ± 805.2 | 150 |
| HGel-NLCDTX-LDC | 88.06 ± 11.65 | 4377.8 ± 950.8 | 150 |
Statistical analysis (Tukey’s multiple comparisons test, n = 5) showed no significant differences among the groups (HGel-LDC vs. HGel-NLCCTRL-LDC vs. HGel-NLCDTX-LDC).