Table 5.
Biochemical parameters in the serum of female C57BL/6J mice, after treatment with PBS (positive control), free docetaxel (DTXT-HYD) and hydrogel formulations (HGel-LDC, HGel-NLCDTX TP, HGel-NLCDTX-LDC TP and NLCDTX IT + HGel-LDC TP).
| Groups | ALT (UI/L) (Rf:44.0–87.0) |
AST (UI/L) (Rf:55.0–251.0) |
Creatinine (mg/dL) (Rf: 0.48–1.10) |
Urea (mg/dL) (Rf: 18.0–31.0) |
|---|---|---|---|---|
| Naive | 52.0 ± 6.2 | 144.0 ± 10.5 | 0.66 ± 0.26 | 48.0 ± 18.0 |
| Positive Control | 171.0 ± 8.4 | 20.0 ± 5.7 | 0.68 ± 0.12 | 57.0 ± 14.1 |
| DTXT-HYD IT | 28.0 ± 11.0 | 144.0 ± 3.4 | 0.15 ± 0.09 | 66.0 ± 17.9 |
| HGel-LDC TP | 135.0 ± 16.0 | 36.0 ± 9.0 | 0.57 ± 0.10 | 52.0 ± 16.3 |
| HGel-NLCDTX TP | 34.0 ± 12.0 | 186.0 ± 6.2 | 0.57 ± 0.21 | 43.0 ± 15.5 |
| HGel-NLCDTX-LDC TP | 98.0 ± 14.4 | 213.0 ± 11.4 | 0.38 ± 0.14 | 52.0 ± 15.0 |
| NLCDTXIT + HGel-LDC TP | 45.0 ± 17.0 | 51.0 ± 8.4 | 0.52 ± 0.13 | 45.0 ± 19.0 |
NOTE: ALT, alanine aminotransferase. AST, aspartate aminotransferase. Values represented as mean ± standard error. Rf = reference range adapted from [82], Comp. Med. 2004.