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. 2021 Oct 19;13(20):3594. doi: 10.3390/polym13203594

Table 2.

Kinetic models used to calculate FA release from the nanofibers.

Kinetic Model Equation
Zero-order Qt=k0t+Q0
Qt: Drug concentration at time t
Q0: Initial drug concentration
k0: Zero order rate constant
First-order logQt=logQ0kt /2303
Q: Drug concentration released at time t
Q0: Initial drug concentration
k: First order rate constant
Higuchi (Power Law) Qt=kh t1/2
Q: Drug concentration at time t
kh: Higuchi release rate constant
Hixson-Crowell  Q01/3 Qt13=kh
Q0: Initial drug amount
Qt: Drug amount at time t
k: Hixson–Crowell rate constant
Korsmeyer–Peppas QtQ=ktn
Qt: Drug concentration at time t
Q∞: Equilibrium drug concentration in the release medium
Qt/Q∞: Drug fraction in the release medium at time t
k: Release rate constant
n: Diffusional exponent