Zero-order |
|
Qt: Drug concentration at time t |
Q0: Initial drug concentration |
k0: Zero order rate constant |
First-order |
|
Q: Drug concentration released at time t |
Q0: Initial drug concentration |
k: First order rate constant |
Higuchi (Power Law) |
|
Q: Drug concentration at time t |
kh: Higuchi release rate constant |
Hixson-Crowell |
|
Q0: Initial drug amount |
Qt: Drug amount at time t |
k: Hixson–Crowell rate constant |
Korsmeyer–Peppas |
|
Qt: Drug concentration at time t |
Q∞: Equilibrium drug concentration in the release medium |
Qt/Q∞: Drug fraction in the release medium at time t |
k: Release rate constant |
n: Diffusional exponent |