Figure 7.

Overall structure of the Dengue NS2B-NS3 heterodimer, which harbors the protease needed for releasing viral proteins from the precursor (A). Close-up of the linker connecting the protease and helicase domains of NS3 (B). The protease domain is shown in green, the helicase domain is colored in blue, and the activating peptide of NS2B is yellow. The ten amino acids linker, connecting the two enzymatically independent domains of NS3, is shown in pink (carbon backbone). Within the linker, oxygen and nitrogen atoms are shown in red and blue, respectively. The PDB accession number of the structure shown is 2VBC [193].