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The nuclear envelope. Emerin, Lap2β, and MAN1 bind to lamins at the inner nuclear membrane of the nuclear envelope, where they perform diverse functions within the nucleus. Emerin regulates gene expression by regulating chromatin architecture through binding to HDAC3 and transcription factors (GCL, β-catenin, Lmo7, and Btf) and altering signaling pathways. Created with BioRender.com.
