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Functional map based on emerin missense mutations that disrupt binding to specific partners. (A) Summary of binding results for each named partner, tested for binding to each mutation. Scoring: Normal binding (+), weakened binding (± and gray), and undetectable binding (black box). nt, not tested. (B) Results from (A) mapped to the emerin polypeptide. APC-L, APC-like domain; TM transmembrane domain; LEM, Lap2, emerin, MAN1, domain [58]. Created with BioRender.com.
