Table 1.

IC₅₀ of the drugs.

Drug	BEZ235	LY294002	Rapamycin	Gefitinib	Cisplatin
Category	PI3K/mTOR inhibitor	PI3K inhibitor	mTOR inhibitor	EGFR inhibitor	Platinum chemotherapy
FaDu *
Parental	50 nM	19.8 μM	0.6 μM	1.0 μM	1.30 μM
200r	850 nM	44.7 μM	>10 μM	8.8 μM	3.85 μM
1000r	>1500 nM	43.45 μM	>10 μM	20 μM	4.59 μM
UMSCC1 *
Parental	16.39 nM	18.14 μM	>50 μM	3.85 μM	5.64 μM
200r	>500 nM	44.35 μM	>50 μM	>50 μM	3.12 μM

* The resistant cells were developed by prolonged incubation with 200 nM (200r) or 1000 nM (1000r) BEZ235.