Table 1.

Studies employing next generation sequencing targeting 16S rRNA to unravel the microbiome in various specimen types of HS patients.

Study Group	Specimen	Findings	Comments
Riverain-Gillet et al. [63]	Skin surface of non-lesional skin swab	Fourteen bacterial taxa statistically discriminated HS from healthy control skin were predominantly Prevotella but also Actinomyces, Campyobacter ureolyticus, and Mobiluncus.	Bacterial richness is similar between HS skin and skin of healthy controls. Evenness is significantly higher in HS skin samples. The microbiome of clinically unaffected intertriginous skin in HS patients is characterized by an anaerobic shift contrasting with a decreased abundance of aerobic skin commensals.
H C Ring et al. [64]	Lesional HS skin biopsy	Dominated by Corynebacterium spp., Prophyromonas, and Peptoniphilus spp.	No difference in richness between three groups.
	Non-lesional HS skin biopsy	Dominated by Acinetobacter and Moraxella spp.
	Healthy control skin biopsy	Equally distributed microbiome.
H C Ring et al. [65]	Tunnels	Dominated by anaerobic species (Prophyromonas spp and Prevotella spp.).
H C Ring et al. [66]		Consistent levels of various bacteria such as Acinetobacter and Moraxella, which do not differ significantly between control and HS blood.	Source of bacteria is likely from skin of the antecubital fossa discovered due to high sensitivity of NGS.
Hispan et al. [67]		Presence of bacterial DNA was significantly higher in HS group vs. control. Dominant species was E. coli.