Table 1.
Potency, cytotoxicity and selectivity indexes of ion-channel inhibitors in vitro.
| VeroE6 cells | EC50 (µM) a | CC50 (µM) b | SI c |
|---|---|---|---|
| Inhibitor | |||
| Amantadine | 116 | 1411 | 12.2 |
| Memantine | 80 | 611 | 7.6 |
| Rimantadine | 36 | 621 | 17.3 |
| Huh7.5 cells | EC50 (µM) a | CC50 (µM) b | SI c |
| Inhibitor | |||
| Amantadine | 118 | 659 | 5.6 |
| Memantine | 86 | 218 | 2.5 |
| Rimantadine | 26 | 159 | 6.1 |
| A549-hACE2 cells | EC50 (µM) a | CC50 (µM) b | SI c |
| Inhibitor | |||
| Amantadine | 80 | >1429 | >17.9 |
| Memantine | 70 | 591 | 8.4 |
| Rimantadine | 70 | 1374 | 19.6 |
a EC50, median effective concentration against SARS-CoV-2. b CC50, median cytotoxic concentration; for amantadine in A549-hACE2 cells, >50% cell viability was observed at the highest concentrations tested. c SI, selectivity index, CC50/EC50.