Table 5.

Advantages and Disadvantages of transgenic TCR vs. CAR T cell-based therapy.

	Transgenic TCR T Cells	CAR T Cells
Advantages	○Recognize peptides derived from intracellular and extracellular proteins ○High antigen sensitivity (as little as 1 antigen per cell needed) ○Target antigen may be tumor-specific (neoantigen-derived)	○Kills cancer cells at a log-scale [91] ○MHC-independent ○Not dependent on mutations and neoantigen expression
Disadvantages	○Receptor is MHC-restricted, necessitating MHC-matching ○Identifying target antigen and patient-specific TCR remains challenging ○Severe toxicities	○Only targets extracellular proteins ○Severe toxicities, including cytokine release syndrome ○Lower antigen sensitivity (>100 antigens per cell needed, in general)