Table 1.
Demographics, sample information, and variability.
| Patient Characteristics (n = 43) | |
|---|---|
| Age (years), median (IQR) | 66 (58–70) |
| Sex (male), n (%) | 28 (65) |
| Body weight (kg), median (IQR) | 70 (61–87) |
| BMI (kg/m2), median (IQR) | 25 (21–28) |
| APACHE II score (n = 41), | |
| median (IQR) | 18 (14–24) |
| n (%), < 15 | 11 (27) |
| ≥15 | 30 (73) |
| Length of ICU-stay (days), median (IQR) | 22 (14–37) |
| Number of patients who received a loading dose, n (%) | |
| Yes | 25 (58) |
| No | 14 (33) |
| Unknown (transfer to other hospital) |
4 (9) |
| Number of patients that received a loading dose (yes/no), n (%) | |
| Yes | 18 (78) |
| No | 5 (22) |
| Number of patients with at least one subtherapeutic | 17 (40) |
| (<15 mg/L) fluconazole trough concentration, n (%) | |
| Fluconazole Concentrations (n = 288) | |
| Number of samples per patient, median (IQR) | 7 (3–10) |
| Fluconazole Cmin (mg/L), median (IQR) | 22.9 (14.7–35.2) |
| Fluconazole dose (mg/kg), median (IQR) | 5.3 (4.5–7.0) |
| Fluconazole dose (mg), median (IQR) | 400 (400–400) |
| Fluconazole dose (mg), n (%) | |
| 50 | 9 (3) |
| 200 | 28 (10) |
| 400 | 206 (72) |
| 600 | 1 (0.35) |
| 800 | 40 (14) |
| 1000 | 1 (0.35) |
| 1200 | 3 (1) |
| Administration route (PO), n (%) | 28 (10) |
| SOFA score on day of sampling (n = 273), median (IQR) | 7 (4–11) |
| Variability | |
| %CV intrasubject | 28.3 |
| %CV intersubject | 50.5 |
IQR: interquartile range; ICU: intensive care unit; PO: oral; %CV: coefficient of variation; Cmin: trough concentration.