Table 4.
Target nonattainment, depending on loading dose and day of fluconazole treatment.
| Loading Dose | ||||
|---|---|---|---|---|
| Yes (n = 161 *) | No (n = 90 *) | |||
| Cmin < 15 mg/L | Cmin > 80 mg/L | Cmin < 15 mg/L | Cmin > 80 mg/L | |
| Day 3 | 4/11 (36%) | 0/11 (0%) | 1/2 (50%) | 0/2 (0%) |
| Day 4 | 4/12 (33%) | 0/12 (0%) | 2/4 (50%) | 0/4 (0%) |
| Day 5 | 3/13 (23%) | 0/13 (0%) | 4/5 (80%) | 0/5 (0%) |
| Day 6 | 4/15 (27%) | 0/15 (0%) | 2/7 (29%) | 0/7 (0%) |
| Day 7 | 4/18 (22%) | 0/18 (0%) | 2/5 (40%) | 0/5 (0%) |
| Day 8 | 2/17 (12%) | 0/17 (0%) | 2/6 (33%) | 0/6 (0%) |
| Day 9 | 1/17 (6%) | 1/17 (6%) | 2/6 (33%) | 0/6 (0%) |
| Day 10 | 0/11 (0%) | 0/11 (0%) | 2/6 (33%) | 0/6 (0%) |
| Day > 10 | 4/47 (9%) | 0/47 (0%) | 12/49 (25%) | 0/49 (0%) |
* In 37 samples (four patients) it could not be assessed if a loading dose was administered (as patients were transferred from another hospital to ours).