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. 2021 Sep 24;13(10):1553. doi: 10.3390/pharmaceutics13101553

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ML111-induced accumulation of APC/C substrates in SK-N-MC cells. (A) Scatter plot showing relative quantitative enrichment of 7122 proteins by mass spectrometry in response to ML111 relative to vehicle control in SK-N-MC cells. Known cell cycle proteins upregulated > 1.5-fold (log2 > 0.58) are shown in blue. (B) Diagram showing where the accumulating APC/C substrates would normally be ubiquitinated by the APC/C complex in the cell cycle. The diagram illustrates the dependence the cell cycle progression on APC/C co-activators CDC20 and CDH1, the spindle assembly checkpoint (SAC), mitotic checkpoint complex (MCC), and the location in the cell cycle where various substrates are expected to be ubiquitinated.