Table 1.

Significantly altered metabolites in the serum of COVID-19-positive patients with observed fold changes.

Name	Molecular Weight	Log2 Fold Change: (Co)/(Re)	p-Value: (Co)/(Re)
Lipid and Lipid metabolites
SM(d34:2)	700.55	1.70	0.02
PC(O-34:2)	743.58	0.82	0.03
PC(O-38:6)	791.58	0.74	0.05
PC(O-32:0)	719.58	0.39	0.06
PC(O-38:5)	793.60	0.53	0.04
PC(O-36:4)	767.58	0.96	0.08
PC(16:0 > PC(0:0/16:0)	495.33	0.19	0.01
FA(20:4)	304.24	1.82	0.04
Oleoyl-L-α-lysophosphatidic acid	436.26	0.76	0.02
Hexadecanoicacid	256.24	0.25	0.05
1_6_6-Trimethyl-2_7-dioxabicyclo[3.2.2]nonan-3-one	184.11	−0.56	0.02
9_12-Dioxododecanoicacid	228.14	−0.70	0.01
LPC(16:0) > LPC(16:0/0:0)_and_LPC(0:0/16:0) 2M + H2CO2	541.34	0.42	0.08
LPE(18:0) > LPE(18:0/0:0)_and_LPE(0:0/18:0)	481.32	0.61	0.01
Amino Acid and Amino acid metabolites
DL-Tryptophan	204.09	0.64	0.01
Indole;1-Benzazole	117.06	0.53	0.03
2-Hydroxypyridine	95.04	−2.13	0.05
Indole-3-acrylic acid	187.06	0.37	0.03
Glycine	75.03	0.98	0.05
Guanidineacetic acid	117.06	0.33	0.02
L-2-Amino-3-oxobutanoicacid	117.04	0.79	0.04
(3R)-beta-Leucine	131.09	0.47	0.04
(S)-Methylmalonatesemialdehyde	102.03	1.17	0.02
N5-Ethyl-L-glutamine	174.10	−2.32	0.04
Urocanic acid	138.04	−0.89	0.02
Drug Metabolites
Thebaine	311.15	1.87	0.01
1_2-Diaminobenzene	108.07	0.89	0.10
Ecgonine	185.11	0.64	0.04
4,4’-Bipyridine	174.08	0.35	0.02
8-Hydroxyquinoline	145.05	0.36	0.03
1-Methylpyrrolinium	83.07	0.21	0.03
3-Methyl-quinolin-2-ol	159.07	0.35	0.03
Isoquinoline	129.06	0.31	0.02
Others
Ectoine	142.07	1.59	0.03
cis-Zeatin	219.11	−2.10	0.05
2-methylhistamine	125.10	0.91	0.10
Glycocholic acid	465.32	0.66	0.02
Creatinine	113.06	−0.31	0.04
2-Oxoglutaric acid	146.02	1.13	0.04