Table 1.
Antibiotics and secondary metabolite analysis of complete biosynthetic gene clusters in strain M34.
| Region | Type | Most Similar Gene Cluster | Similarity (%) | |
|---|---|---|---|---|
| Scaffold1 | 1.1 | NRPS 1, T1PKS 2 hybrid | leupyrrin | 20% |
| Scaffold1 | 1.2 | NRPS | VEPE/AEPE/TG-1 | 100% |
| Scaffold2 | 2.1 | NRPS, T1PKS hybrid | myxoprincomide-c506 | 66% |
| Scaffold2 | 2.2 | RiPP 3 (RRE-containing 4) | - | - |
| Scaffold3 | 3.1 | thioamitides | - | - |
| Scaffold3 | 3.2 | NRPS, T1PKS hybrid | nostopeptolide A2 | 50% |
| Scaffold5 | 5.1 | RiPP (RRE-containing) | - | - |
| Scaffold6 | 6.1 | RiPP (RRE-containing) | - | - |
| Scaffold11 | 11.1 | RiPP (RRE-containing) | - | - |
| Scaffold14 | 14.1 | RiPP (RRE-containing) | - | - |
| Scaffold16 | 16.1 | T1PKS, NRPS hybrid | DKxanthene | 82% |
| Scaffold17 | 17.1 | T1PKS | - | - |
| Scaffold18 | 18.1 | NRPS | chloromyxamide | 13% |
| Scaffold23 | 23.1 | RiPP (RRE-containing) | - | - |
| Scaffold24 | 24.1 | terpene | carotenoid | 100% |
| Scaffold26 | 26.1 | T3PKS 5 | alkylpyrone-407/alkylpyrone-393 | 54% |
| Scaffold42 | 42.1 | T1PKS | sporolide A/sporolide B | 10% |
| Scaffold47 | 47.1 | RiPP (RRE-containing) | - | - |
1 Non-ribosomal peptide synthetase. 2 Type I polyketide synthase. 3 Ribosomally synthesized and post-translationally modified peptide. 4 RiPP recognition element (domains that can identify and bind the RiPP precursor peptide). 5 Type Ⅲ polyketide synthase.