Table 2.

Continent/country-wise prevalence of adaptive mutations in the receptor-binding domain of the SARS-CoV-2 spike protein until 29 May 2021.

Continent/Country	No. of Studied Sequences	Mutation (%)
		R346K	K417N	K417T	N439K	L452Q	L452R	Y453F	S477N	T478K	T478R	E484K	E484Q	F490S	S494P	N501Y
Africa	1728		0.347		0.289		5.845	0.058	1.678	0.058		4.456	0.174		0.058	9.028
Asia	3703	0.135	1.242	0.351	0.270	0.027	1.836		0.513	1.053		1.782	0.702	0.189		7.399
Europe €	6092	0.033	0.509	0.312	1.346		0.575	0.230	5.368	0.066		1.625	0.033		0.657	26.133
Switzerland	18,234	0.362	0.516	0.126	4.442	0.005	1.475	0.016	21.213	0.801		0.856	0.038	0.033	0.104	17.906
UK	178,878	0.003	0.084	0.004	1.348	0.002	0.070	0.004	1.094	0.010	0.007	0.214	0.013	0.051	0.323	51.055
North America ‡	99								2.020			9.091				1.010
USA	300,280	0.041	0.424	3.147	0.034	0.119	11.556	0.010	2.836	3.067	0.040	9.005	0.089	0.162	1.721	39.631
Oceania	13,299								75.848						0.008	0.278
South America	603			0.663		4.312						1.990		4.312		0.995

^€ = Europe excluding Switzerland and the UK; ^‡ = North America excluding the USA; empty cell = 4 or more decimal places or 0%.