Table 3.

Final pharmacodynamic model ^a parameter estimates.

Parameter (Units)	Estimate	Bootstrap Median (95% CI)
Kout (day−1)	0.0581	0.0641 (0.0249–0.110)
FC0 (mg/kg)
Patients without ulcers at baseline	102	105 (54.4–188)
Patients with ulcers at baseline	213	214 (157–287)
Emax (%)	219	227 (128–442)
C50 (nmol/L)	2.46	2.56 (0.413–13.9)
Interindividual variability
IIV FC0 (%) b	99.0 (2)	98.0 (75.0–128)
Residual variability
Proportional RUV (%) b	57.3 (17)	56.4 (48.8–65.0)

CI—confidence interval; K_out—fecal calprotectin degradation rate constant; FC₀—baseline fecal calprotectin concentration; E_max—maximum effect; C₅₀—target concentration at half-maximum effect; IIV—interindividual variability; RUV—residual unexplained variability. ^a. $\frac{dFC}{dt}=\frac{F{C}_0\times K_{out}}{1+\frac{E_{max}\times \frac{K_{syn}}{K_{deg}}}{C_{50}+\frac{K_{syn}}{K_{deg}}}}\times \left(1+\frac{E_{max}\times unbound target concentration}{C_{50}+unbound target concentration}\right)-K_{out}\times FC$. ^b. For variability terms % shrinkage is presented in brackets.