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Melatonin metabolic pathway. Melatonin is synthesized from tryptophan and serotonin by a series of enzymes. * AA-NAT enzyme is the rate-limiting enzyme of this pathway. Melatonin is catabolized by cytochrome P450 enzymes (like CYP1A2) into 6-hydroxymelatonin. ** 6-hydroxymelatonin can be excreted or sulfated and then excreted.
