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Permeation profiles of reconstructed human epidermis (SkinEthic®) using flufenamic acid at infinite dose regime of: dissolved drug in hydrogel (FFA HG), FFA-loaded nanoparticles dispersed in the hydrogel (FFA NP HG), and dissolved drug with drug-free nanoparticles dispersed in the hydrogel (FFA HG + DF-NP). Concentration of FFA 0.125 µg/g.
