Table 4.
Saturation concentration and ionized percentage of flufenamic acid in different solvents at 32 °C (mean ± SD).
| Solvent | Saturation Concentration (µg/mL) | Ionized Percentage (%) | Non-Ionized Percentage (%) | |
|---|---|---|---|---|
| Water | 5.8 ± 0.8 | n.d. | n.d. | |
| Soerensen buffer | pH 6.0 | 29.4 ± 0.4 | 99.21 | 0.79 |
| McIlvaine buffer | pH 3.4 | 1.8 ± 0.2 | 24.00 | 76.00 |
| pH 4.4 | 5.6 ± 0.5 | 75.97 | 24.03 | |
| pH 5.4 | 43.1 ± 1.8 | 96.93 | 3.07 | |
| pH 6.4 | 383.4 ± 14.2 | 99.68 | 0.32 | |
| pH 7.4 | 2896.1 ± 55.9 | 99.97 | 0.03 | |
| Soerensen buffer | pH 7.4 * | 2059.5 ± 21.6 | 99.97 | 0.03 |
* data were taken from [33]. n.d.: not determined.