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Representation of the classical PGR gene found in chromosome 11, and as of the protein domains of PGR isoforms A, B, and C. In response to estrogen binding to ERE, the PGR gene codifies for the distinct isoforms by the influence of different promoters. ERE = estrogen response elements. AF = activation function domain. ID = inhibitory domain. DBD = DNA-binding domain. LBD = ligand-binding domain. NH2 = amino terminal region. COOH = carboxyl terminal region.
