Table 3.
The most significant differentially expressed genes with their fold changes, P values, and q values.
| Probeset ID | Gene symbol | FC RA + LA AFib vs. SR |
P value | q value (adjusted P value) | FC RA AFib vs. SR |
P value | q value (adjusted P value) | FC LA AFib vs. SR |
P value | q value (adjusted P value) |
|---|---|---|---|---|---|---|---|---|---|---|
| 206801_at | NPPB | 3.46 | 4.16E-04 | 8.65E-04 | 4.45 | 0.002 | 0.005 | 2.68 | 0.037 | 0.042 |
| 243737_at | ATP1B4 | 2.81 | 2.82E-05 | 1.05E-04 | 2.90 | 7.25E-04 | 0.003 | 2.87 | 0.006 | 0.01 |
| 206073_at | COLQ | 2.64 | 1.15E-05 | 5.53E-05 | 3.27 | 8.75E-05 | 0.001 | 2.08 | 0.009 | 0.02 |
| 202718_at | IGFBP2 | 2.61 | 2.07E-04 | 4.87E-04 | 2.56 | 0.015 | 0.018 | 2.64 | 0.001 | 0.0072 |
| 205713_s_at | COMP | 2.47 | 7.52E-05 | 2.30E-04 | 2.12 | 0.013 | 0.016 | 2.64 | 0.005 | 0.015 |
| 228754_at | SLC6A6 | 2.4 | 1.18E-06 | 1.25E-05 | 2.86 | 5.48E-05 | 7.70E-04 | 2.01 | 0.003 | 0.012 |
| 204260_at | CHGB | 2.37 | 1.62E-08 | 1.71E-06 | 2.34 | 2.51E-05 | 5.66E-04 | 2.38 | 2.67E-04 | 0.005 |
| 224009_x_at | DHRS9 | 2.24 | 1.72E-06 | 1.56E-05 | 2.44 | 5.29E-05 | 7.70E-04 | 1.99 | 0.011 | 0.021 |
| 205923_at | RELN | 2.19 | 0.001 | 0.002 | 2.29 | 0.018 | 0.021 | 2.10 | 0.036 | 0.042 |
| 213001_at | ANGPTL2 | 2.09 | 6.74E-08 | 2.13E-06 | 2.07 | 3.83E-06 | 2.00E-04 | 2.12 | 0.001 | 0.008 |
| 201645_at | TNC | 1.84 | 0.002 | 0.003 | 1.69 | 0.0284 | 0.031 | 1.94 | 0.046 | 0.046 |
| 206768_at | RPL3L | 1.93 | 1.16E-04 | 3.14E-04 | 2.24 | 3.74E-04 | 0.002 | 1.63 | 0.003 | 0.0122 |
| 205493_s_at | DPYSL4 | 1.9 | 6.23E-04 | 0.001 | 1.77 | 0.029291 | 0.0314 | 2.04 | 0.008 | 0.018 |
| 208370_s_at | RCAN1 | 1.86 | 7.78E-07 | 8.60E-06 | 2.05 | 3.93E-05 | 7.66E-04 | 1.66 | 0.006 | 0.0169 |
| 225061_at | DNAJA4 | 1.75 | 6.75E-07 | 7.85E-06 | 2.09 | 3.40E-07 | 9.95E-05 | ∗ | ∗ | ∗ |
| 229797_at | MCOLN3 | -2.81 | 2.42E-08 | 1.07E-06 | -2.43 | 4.71E-05 | 7.70E-04 | -3.14 | 2.42E-05 | 9.98E-04 |
| 222927_s_at | CPLX3 | -2.43 | 4.15E-05 | 1.45E-04 | -2.94 | 0.002 | 0.005 | -1.98 | 0.005 | 0.0167 |
| 205177_at | TNNI1 | -2.43 | 3.94E-04 | 8.28E-04 | -3.21 | 0.002 | 0.005 | -1.86 | 0.027 | 0.0366 |
| 207344_at | AKAP3 | -2.39 | 1.76E-06 | 1.56E-05 | -1.99 | 0.008 | 0.01 | -2.80 | 7.41E-05 | 0.002 |
| 222919_at | TRDN | -2.12 | 6.09E-08 | 2.13E-06 | -1.91 | 5.62E-05 | 7.70E-04 | -2.28 | 5.71E-04 | 0.0055 |
| 209693_at | ASTN2 | -1.97 | 1.45E-04 | 3.56E-04 | -2.23 | 0.001 | 0.004 | -1.50 | 0.009 | 0.02 |
| 226228_at | AQP4 | -1.85 | 6.82E-05 | 2.18E-04 | -2.15 | 0.00180054 | 0.0050 | -1.5 | 0.007 | 0.018 |
| 205910_s_at | CEL | -1.81 | 8.54E-05 | 2.48E-04 | -1.99 | 0.003 | 0.006 | -1.62 | 0.005 | 0.015 |
| 221288_at | GPR22 | -1.78 | 2.56E-06 | 2.02E-05 | -1.87 | 9.17E-05 | 0.001 | -1.66 | 0.007 | 0.018 |
| 204121_at | GADD45G | -1.75 | 6.56E-04 | 0.001 | -1.71 | 0.027 | 0.029 | -1.82 | 0.009 | 0.0195 |
| 1559419_at | CACNB2 | -1.70 | 6.83E-04 | 0.001 | -1.72 | 0.004 | 0.007 | -1.60 | 0.035 | 0.0416 |
| 214369_s_at | RASGRP2 | -1.60 | 1.11E-07 | 2.87E-06 | -1.65 | 1.97E-04 | 0.0016 | -1.55 | 2.31E-04 | 0.0032 |
| 209590_at | BMP7 | -1.57 | 6.39E-06 | 3.82E-05 | -1.58 | 7.51E-04 | 0.0033 | -1.54 | 8.67E-04 | 0.0066 |
| 221796_at | NTRK2 | -1.57 | 1.32E-04 | 3.37E-04 | -2.05 | 9.54E-07 | 9.95E-05 | ∗ | ∗ | ∗ |
| 213992_at | COL4A6 | -1.51 | 0.005 | 0.006 | -1.53 | 0.012 | 0.015 | -1.53 | 0.022 | 0.032 |
The most significant 30 genes are chosen according to fold changes. Coexistent transcript Affy IDs in three groups of tissue types (RA + LA, RA, LA) are considered the utmost. Genes in the table were selected, the top 15 of the lists that comparison between AFib and SR (FC ± 1.5) in RA + LA, RA, and LA tissues. Some Affy IDs mentioned with ∗ are not found in all three lists. However, a connection found between that gene and AFib in other studies. RA: right atrium; LA: left atrium; AFib: atrial fibrillation; SR: sinus rhythm; FC: fold change. Presented genes in alphabetical order: AKAP3: A-kinase anchoring protein 3; ANGPTL2: angiopoietin like 2; AQP4: aquaporin 4; ASTN2: astrotactin 2; ATP1B4: ATPase Na+/K+ transporting family member beta 4; BMP7: bone morphogenetic protein 7; CACNB2: calcium voltage-gated channel auxiliary subunit beta 2; CEL: carboxyl ester lipase; CHGB: chromogranin B; COL4A6: collagen type IV alpha 6 chain; COLQ: collagen like tail subunit of asymmetric acetylcholinesterase; COMP: cartilage oligomeric matrix protein; CPLX3: complexin 3; DHRS9: dehydrogenase/reductase 9; DNAJA4: DnaJ heat shock protein family (Hsp40) member A4; DPYSL4: dihydropyrimidinase like 4; GADD45G: growth arrest and DNA damage inducible gamma; GPR22: G protein-coupled receptor 22; IGFBP2: insulin like growth factor binding protein 2; MCOLN3: mucolipin TRP cation channel 3; NPPB: natriuretic peptide B; NTRK2: neurotrophic receptor tyrosine kinase 2; RASGRP2: RAS guanyl releasing protein 2; RCAN1: regulator of calcineurin 1; RELN: reelin; RPL3L: ribosomal protein L3 like; SLC6A6: solute carrier family 6 member 6; TNC: tenascin C; TNNI1: troponin I1, slow skeletal type; TRDN: triadin.