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. 2021 Oct 13;13(10):2055. doi: 10.3390/v13102055

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Mass spectrometry analysis of intracellular abundance of d-glucose 6-phosphate (an immediate glucose metabolite) showing increased glycolysis in RSV group NAECs. (B) Isotope tracing analysis of conversion of 13C glucose to pentose phosphate pathway intermediate d-sedoheptulose 7-phosphate. Color bars indicate the proportion of metabolite derived from de novo 13C glucose uptake (indicated by number of 13C incorporated carbons (M1-M7), gray indicates metabolite production from native upstream metabolic reactions (no incorporated 13C carbons (M0)). (C) Higher conversion of 13C glucose to succinic semialdehyde (green bars), suggesting aberrant TCA cycle inputs in NAECs from children who were RSV infected as infants. n = 2 independent donors/group. **** p < 0.0001 by two-way ANOVA with Tukey multiple comparisons.