Table 1.

Gibbs energies of binding of viruses. Part (A): Gibbs energies of binding calculated from dissociation constants. The “Reference” column gives sources from which the dissociation constants were taken. Part (B): Gibbs energies of binding calculated from enthalpies and entropies of binding. The “Reference” column gives sources from which the Δ_bH and Δ_bS values were taken. Part (C): Gibbs energies of binding reported in the literature and references from which they were taken. Symbols: K_d—dissociation constant; K_b—binding affinity; Δ_bG—Gibbs energy of binding; Δ_bG—enthalpy of binding; Δ_bS—entropy of binding.

(A) Binding constant
Name	Kd (nM)	Kb (×109 M−1)	ΔbG (kJ/mol)	Reference
Adenovirus	20 to 25	0.040 to 0.050	−45.1 to −45.7	[44]
HIV-1	0.83 to 11.6	0.0862 to 1.2	−53.9 to −47.1	[42]
HIV-2	48.5	0.0206	−43.4	[42]
Human cytomegalovirus	1.1	0.91	−53.2	[42]
Influenza (3SLN)	3200	3.1×10−4	−32.6	[42]
Influenza (6SLN)	2100	4.8×10−4	−33.7	[42]
Parainfluenza virus 1	(20.6 to 90.5) × 103	(1.10 to 4.85) × 10−5	−24.0 to −27.8	[45]
Parainfluenza virus 2	(7.7 to 218.2) × 103	(4.58 to 130) × 10−6	−21.7 to −30.4	[45]
Parainfluenza virus 3	(33.7 to 124.7) × 103	(8.02 to 29.7) × 10−6	−23.2 to −26.6	[45]
Poliovirus	0.21	4.8	−57.5	[42]
Reovirus	0.5	2	−55.2	[42]
Vesicular stomatitis virus	0.15	6.7	−58.3	[42]
(B) Enthalpy and entropy
Name	ΔbH (kJ/mol)	ΔbS (J/mol K)	ΔbG (kJ/mol)	Reference
HIV at 37°C	−263.59	−691.04	−49.26	[40]
HIV at 25°C	−198.2	−472.9	−57.2	[40]
HIV at 4 °C	−97.9	−126.01	−63.0	[40]
Arboviruses	−56.545	−125	−18	[46]
(C) Reported in the literature
Name	ΔbG (kJ/mol)		Reference
SARS-CoV-2	−42.2 to −51.4		[10,26,47,48,49]
Rhinovirus	−28 to −39		[27]