Table 1.
The degrees of substitution (DSs) and antiviral activity of carboxymethylated BOT (CM-BOT) and its sulfonated derivatives (CM-S-BOT-1-3) against herpesvirus (KOS and AR strains).
| HSV-KOS | HSV-AR | |||||
|---|---|---|---|---|---|---|
| Compounds | DSS | a CC50 | b IC50 | c SI | b IC50 | c SI |
| BOT d | 0 | >100 | 39.3 | >2.5 | 47.5 | >2.1 |
| CM-BOT | 0 | >100 | NIL | --- | NIL | --- |
| CM-S-BOT-1 | 0.1 | >100 | 12.4 | >8.0 | 56.0 | >1.8 |
| CM-S-BOT-2 | 0.2 | >100 | 35.0 | >2.8 | 40.0 | >2.5 |
| CM-S-BOT-3 | 0.4 | >100 | >100 | --- | 25.7 | >3.9 |
| Acyclovir | 0 | >500 | 0.13 | >3846 | >8 | >62.5 |
a 50% cytotoxic concentration (μg mL−1). b 50% inhibitory concentration (μg mL−1). c Selectivity Index (CC50/IC50). d Sacchelli et al., 2019 [20]. Nil: no effect.