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. 2021 Sep 24;13(10):3343. doi: 10.3390/nu13103343

Figure 2.

Figure 2

Genomic regions interacting with VD PRS after COJO adjustment for depression status, anxiety status, and GAD score. (a) Depression status, a SNP allele was found to significantly interact with blood VD in depression status; (b) Anxiety status, 2 independent SNP alleles were found to significantly interact with blood VD in anxiety status; (c) Anxiety (GAD score), 8 independent SNP alleles interacted significantly with blood VD in anxiety disorders (GAD score). From the center, the first circos depicts the −log10 p-values of each variant due to double exposure, i.e., the effect of both SNP allele and VD PRS after COJO adjustment. The second circos shows chromosome density. Red dots represent the p < 5 × 10−8 and green dots represent p < 1 × 10−7. The figure was generated using the “CMplot” R script (https://github.com/YinLiLin/R-CMplot) (accessed on 15 February 2021).