Table 2.
The associations between Vitamin D traits and traits of depression and anxiety.
| Outcome Variable | Independent Variable | Beta | SE | T | p−Value | OR |
|---|---|---|---|---|---|---|
| Depression status | Blood VD | −0.12 | 0.01 | −18.57 | 5.92 × 10−77 | 0.89 |
| VDPRS After COJO | −0.014 | 0.006 | −2.36 | 1.84 × 10−2 | 0.99 | |
| VDPRS Before COJO | −0.012 | 0.006 | −2.07 | 3.82 × 10−2 | 0.99 | |
| Anxiety status | Blood VD | −0.080 | 0.01 | −9.77 | 1.46 × 10−22 | 0.92 |
| VDPRS After COJO | 0.00 | 0.01 | −0.29 | 7.71 × 10−1 | 1.00 | |
| VDPRS Before COJO | 0.00 | 0.01 | −0.32 | 7.47 × 10−1 | 1.00 | |
| Depression (PHQ score) |
Blood VD | −0.062 | 0.003 | −20.81 | 5.95 × 10−96 | – |
| VDPRS After COJO | −0.007 | 0.003 | −2.61 | 9.15 × 10−3 | – | |
| VDPRS Before COJO | −0.006 | 0.003 | −2.14 | 3.25 × 10−2 | – | |
| Anxiety (GAD score) |
Blood VD | −0.030 | 0.00 | −9.56 | 1.21 × 10−21 | – |
| VDPRS After COJO VDPRS | −0.010 | 0.00 | −2.57 | 1.02 × 10−2 | – | |
| Before COJO | −0.010 | 0.00 | −2.02 | 4.36 × 10−2 | – |
Abbreviations: SE, standard error; T, t−test; OR, odd ratios; VD, vitamin D; VDPRS, polygenic risk score of vitamin D; COJO, conditional and joint analysis; PHQ score, patient health questionnaire (PHQ) is used to describe the depression; GAD score, general anxiety disorder (GAD) is used to describe the anxiety of the participants. Note. Logistic regression was used to evaluate the association between blood VD, VD PRS before COJO adjustment, VD PRS after COJO adjustment and self-reported depression and anxiety. Linear regression was used to evaluate the association between blood VD, VD PRS before COJO adjustment, VD PRS after COJO adjustment and PHQ score, GAD score.