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. 2021 Oct 9;13(10):1649. doi: 10.3390/pharmaceutics13101649

Figure 1.

Figure 1

Applications of CRISPR/Cas9 system. (A) Schematic illustration of the molecular mechanism of CRISPR/Cas9 system. (B) The dCas9 fused to a transcriptional inhibitor (red shape) can repress transcription. (C) A DNA base editor consists of a dCas9 and an adenine or cytosine deaminase (yellow) that converts A to G or T to C, respectively. (D) The dCas9 fused to transcriptional activator (green) can boost transcription. (E) The dCas9 fused with enzymes (blue) that can modify epigenetic marks of DNA can be used to change gene expression status (Created with BioRender.com, accessed on 5 September 2021).