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. 2021 Oct 9;13(10):1649. doi: 10.3390/pharmaceutics13101649

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Fast and efficient Cas9 mRNA and sgRNA delivery by bioreducible lipid nanoparticles. (A) Schematic diagram of BAMEA-O16B lipid nanoparticle for Cas9 mRNA and sgRNA delivery. (B) CLSM images and quantitative analysis of GFP expression of HEK-GFP cells. BAMEA-O16B nanoparticles showed complete loss of GFP fluorescence, while Cas9 mRNA/sgGFP alone did not show a comparable outcome. GFP knockout efficiency can increase to higher than 90%. (C) The mouse serum PCSK9 level decreased to 20% of control group after intravenous injection of BAMEA-O16B nanoparticles. Reproduced with permission from [54]. Copyright Joh Wiley and Sons, 2019.