Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of the viral vectors in clinical trials: AAV, LV, and AV.
| Vector Type | Package Limitation | Superiority | Deficiency | References |
|---|---|---|---|---|
| AAV | 4.5 kb | low immunogenicity, serotype-related targeting, stable transgene expression | low packaging capacity | [32] |
| LV | 8 kb | large packaging capacity, low cell cycle tendency | long lasting expression of Cas9 | [33] |
| AV | >8 kb | large packaging capacity, no-integration to host genome | high immunogenicity | [17] |
