Table 1.
Quantitative analysis of vascular function after treatment with DuraGraft® against ischemia/reperfusion (IR) injury.
| Control | IR | IR + Duragraft | |
|---|---|---|---|
| PE (%) to KCl pD2 to PE |
80.9 ± 3.2 7.49 ± 0.08 |
443.4 ± 61.2 * 7.54 ± 0.08 |
116.3 ± 6.6 *,# 8.05 ± 0.15 *,# |
| KCl (g) | 4.2 ± 0.1 | 1.3 ± 0.2 * | 2.6 ± 0.1 *,# |
| Rmax to ACh (%) | 80,2 ± 2.2 | 47.8 ± 3.0 * | 72.9 ± 1.8 # |
| pD2 to ACh | 7.39 ± 0.06 | 6.27 ± 0.20 * | 7.05 ± 0.12 # |
| Rmax to SNP (%) | 100.0 ± 0.0 | 100.0 ± 0.0 | 94.0 ± 2.0 *# |
| pD2 to SNP | 8.99 ± 0.16 | 8.68 ± 0.09 | 7.65 ± 0.21 *# |
Data are represented as mean ± SEM. PE indicates phenylephrine and was expressed as a percentage of the maximum contraction induced by 80 mM potassium chloride (KCl); ACh indicates acetylcholine; SNP, sodium nitroprusside; Rmax, maximum relaxation, and pD2, negative logarithm of the corresponding half-maximal response (EC50). * p < 0.05 versus control; # p < 0.05 versus IR. n = 21–36 aortic rings from 7–9 rats/group.