Figure 5.
Bioluminescence imaging reflects the decreased fungal burden because of antifungal treatment. Ten mice per group were infected with 2.5 × 108 C. glabrata cells directly into the bladder. The treated group was injected intraperitoneally with fluconazole (50 mg/mL) on a daily basis. Luminescence in the bladders was measured on day one and three post infection. (A) Luminescence in the bladders upon fluconazole treatment (paired t-test, p = 0.0439) (left). Luminescence in the bladders of treated mice is significantly lower compared to untreated mice (unpaired t-test, p = 0.0167) (right). (B) Fungal burden in the bladders and the kidneys upon fluconazole treatment (unpaired t-test, p < 0.0001 and p = 0.0007, respectively). All error bars show standard deviations. Significance: **** p < 0.0001, *** p < 0.001, * p < 0.05.