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. 2021 Oct 15;10(10):1330. doi: 10.3390/pathogens10101330

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The arrangement of EBOV genes is presented at the top, where the symbol indicates the overlapping genes. Transcriptional editing of the GP gene by L protein results in three RNA transcripts: pre-sGP, pre-GP, and pre-ssGP. Translation of these three transcripts results in three pre-proteins, namely, pre-sGP, pre-GP0, and pre-ssGP, respectively. Pre-sGP is cleaved post-translationally by furin into sGP and Δ-peptide. pre-GP₀ and pre-ssGP result in full-length transmembrane spike glycoprotein (GP) and soluble small-secreted glycoprotein (ssGP). GP is cleaved by furin into GP1 and GP2 subunits held together by disulfide bonds. Shed GP is released from infected cells due to cleavage of GP by tumor necrosis factor α-converting enzyme (TACE).

Inline graphic — The arrangement of EBOV genes is presented at the top, where the symbol indicates the overlapping genes. Transcriptional editing of the GP gene by L protein results in three RNA transcripts: pre-sGP, pre-GP, and pre-ssGP. Translation of these three transcripts results in three pre-proteins, namely, pre-sGP, pre-GP0, and pre-ssGP, respectively. Pre-sGP is cleaved post-translationally by furin into sGP and Δ-peptide. pre-GP₀ and pre-ssGP result in full-length transmembrane spike glycoprotein (GP) and soluble small-secreted glycoprotein (ssGP). GP is cleaved by furin into GP1 and GP2 subunits held together by disulfide bonds. Shed GP is released from infected cells due to cleavage of GP by tumor necrosis factor α-converting enzyme (TACE).