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. 2021 Oct 15;10(10):1330. doi: 10.3390/pathogens10101330

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A schematic representation of EBOV nucleoprotein (NP). NP aa 1–450 are involved in RNA encapsidation, NP oligomerization, nucleocapsid (NC) as well as NP-VP35 interaction (along with aa 481–500). aa 562–567 and 581–591 consist of LxxIxE and SxPxLE motifs, respectively, interacting with different host proteins. PPxPxY motif amongst aa 600–617 is significant for NP-VP30 interaction. Interaction of these three motifs with their respective targets is significant to regulate viral transcription.