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. 2021 Oct 15;10(10):1330. doi: 10.3390/pathogens10101330

Figure 7.

Figure 7

A schematic representation of EBOV glycoprotein (GP). GP aa 54–201 form the receptor-binding domain (RBD) or receptor binding site (RBS) responsible for attachment to host cell-surface receptors. Cathepsin cleavage site is present in aa 190–213, and proteolysis via cathepsins is significant for viral infectivity. GP is cleaved at aa 501 by furin into GP1 and GP2 subunits. The immunosuppressive motif (aa 585–609) plays a role in bystander lymphocyte apoptosis and cytokine dysregulation. The transmembrane anchor domain (TMD; aa 650–672) helps tether GP onto the viral surface.