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. 2021 Oct 15;10(10):1330. doi: 10.3390/pathogens10101330

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A schematic representation of EBOV L protein. It has five domains, namely, (a) RdRp domain responsible for polyadenylation and transcription/replication (via GDNQ motif), (b) capping domain with PRNTase activity which caps mRNA co-transcriptionally via transfer of a GDP molecule, (c) connector domain, (d) methyltransferase domain involved in methylation of capped mRNA, as well as cap-independent methylation of internal mRNA adenosine, and (e) C-terminal domain responsible for the regulation of methylation activities of methyltransferase domain. L aa 1–380 are involved in L-VP35 interaction, enabling L’s re-localization into viral inclusion bodies.