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The dorsal and ventral side of the embryonic pituitary generate proliferative and positional signals which regulate the expression of transcription factors. The T-PIT signal differentiates the most dorsal cells into corticotropes (C). Pit1 is induced in the caudomedial region of the pituitary gland, which ultimately gives rise to somatotropes (S), lactotropes (L), and thyrotropes (T). On the ventral side when GATA, SF1, ERBa are activated, the gonadotrope lineage (G) is determined.
